Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®.

@article{Liu2015CharacterizationAP,
  title={Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®.},
  author={Jinwen Liu and Meijuan Zou and Hongyu Piao and Yijing Liu and Bo Tang and Ying Gao and N Ma and Gang Cheng},
  journal={Molecules},
  year={2015},
  volume={20 6},
  pages={11345-56}
}
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim of this study was to improve the physicochemical properties and bioavailability of a poorly water-soluble aprepitant by preparation of solid dispersions. The solid dispersions were characterized by dissolution, FTIR, XRPD, DSC, SEM and pharmacokinetic studies in rats. The dissolution rate of the aprepitant was significantly… CONTINUE READING