• Corpus ID: 18013013

Characterization and Biocompatibility Study of Nematic and Cholesteryl Liquid Crystals

@inproceedings{Soon2009CharacterizationAB,
  title={Characterization and Biocompatibility Study of Nematic and Cholesteryl Liquid Crystals},
  author={Chin Fhong Soon and Mansour Youseffi and Nicholas Blagden and Rebecca F Berends and Samira Batista Lobo and Farideh A. Javid and Morgan C. Denyer},
  year={2009}
}
Intensive research in bio-engineering has been conducted in the search for flexible biomaterials that could support cell growth and cells attachment. Flexible synthetic materials that support cell growth without the aid of synthetic extracellular matrix proteins are still rare. Cholesteryl liquid crystal containing cholesteryl moieties may have suitable biological affinity. Human keratinocytes (HaCat) were cultured with a nematic liquid crystal and three cholesteryl liquid crystals of different… 

Figures from this paper

Surface Properties of Cholesteryl Ester Liquid Crystal
Bio-compatible materials are thought to be very important in many biomedical applications [1]. Recently, a research found that cholesteryl ester liquid crystal (CELC) as a new biomaterial could be
Biophysical characteristics of cells cultured on cholesteryl ester liquid crystals.
TLDR
The biophysical expressions of cells on biocompatible CELC suggested that CELCs could be a new class of biological relevant material.
Effects of an enzyme, depolymerization and polymerization drugs to cells adhesion and contraction on lyotropic liquid crystals
A novel cell force transducing assay based on liquid crystals has been developed. Human keratinocytes (HaCaTs) attached to and formed localized deformation on the surface of highly flexible
Critical Surface Tension of Cholesteryl Ester Liquid Crystal
Cholesteryl ester liquid crystal was found to be non-toxic and it was recently applied as a cell traction force sensor. The reason for the affinity of the cells to this liquid crystal is unclear and
Influence of Time Dependent Factors to the Phases and Poisson's ratio of Cholesteryl Ester liquid crystals
Liquid crystal based biosensors detect physical restructuring of cells via changes in the birefringence property or orientation order of the liquid crystal molecules. The strain induced in the liquid
Biomineralized Composite Liquid Crystal Fiber Scaffold Promotes Bone Regeneration by Enhancement of Osteogenesis and Angiogenesis
  • Yi Zhan, Bing Deng, +4 authors Zhixiong Pan
  • Medicine
    Frontiers in Pharmacology
  • 2021
TLDR
In vivo studies showed that the HAP-PLLA/LC scaffold with a bone-like environment significantly accelerates new and mature lamellar bone formation by development of a microenvironment for vascularized bone regeneration.
A Squeegee Coating Apparatus for Producing a Liquid Crystal Based Bio-Transducer
Cholesteryl ester liquid crystals were discovered with a new application in sensing traction forces of single cells. The liquid crystal bio-transducer is produced by manual scraping of liquid
A squeegee coating apparatus for producing a liquid crystal based bio-transducer
Cholesteryl ester liquid crystals were discovered with a new application in sensing traction forces of single cells. The liquid crystal bio-transducer is produced by manual scraping of liquid
Cell Traction Force Mapping in MG63 and HaCaTs
The ability of a cell to adhere and transmit traction forces to a surface reveals the cytoskeleton integrity of a cell. Shear sensitive liquid crystals were discovered with new function in sensing
Effects of trypsin and cytochalasin-B treatments to cell traction forces
This study aimed at characterizing the responses and cell traction forces of keratinocytes after treated with trypsin and cytochalasin-B using a liquid crystal based cell traction force transducer.
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
Thermotropic Liquid Crystals as Substrates for Imaging the Reorganization of Matrigel by Human Embryonic Stem Cells
We have investigated the culture of human embryonic stem cells (hESCs) on interfaces of the thermotropic liquid crystal, TL205, that are decorated with thin films of the extracellular matrix,
Engineering Interfaces to Cells using Synthetic Liquid Crystals
INTRODUCTION: Given the ubiquitous presence of the liquid crystalline state in biological systems and the technological utility of liquid crystals, it is surprising that few examples of the use of
Liquid-crystal materials find a new order in biomedical applications.
TLDR
New areas of application in the realms of biology and medicine are stimulating innovation in basic and applied research into liquid-crystal materials, leading to new techniques for optically probing biological systems.
Deciphering the interactions between liquid crystals and chemically functionalized surfaces: Role of hydrogen bonding on orientations of liquid crystals
Abstract This paper reports an investigation of the influence of interfacial hydrogen bonding on the orientations of liquid crystals at surfaces. The orientations of 10 liquid crystals were examined
Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane.
TLDR
Results suggest that FC generated by the hydrolysis of cytoplasmic CE is transported through acidic vesicles to the plasma membrane, and accumulation of FC in this pool triggers cell death by necrosis and apoptosis.
Ropivacaine and lidocaine inhibit proliferation of non-transformed cultured adult human fibroblasts, endothelial cells and keratinocytes
TLDR
There seems to be a general correlation between the local anaesthetic potency and the inhibiting effect on cell proliferation, which suggest a mechanism by which local anaesthetics may exhibit anti-hyperproliferative effects in clinical situations.
Cholesteryl esters in malignancy.
  • M. Tosi, V. Tugnoli
  • Biology, Medicine
    Clinica chimica acta; international journal of clinical chemistry
  • 2005
TLDR
The role of different regulatory mechanisms in cholesterol homeostasis in physiologic and neoplastic conditions with emphasis on intracellular content of cholesteryl esters is here reviewed.
Exploratory investigation on the measurement of skin friction by means of liquid crystals
Skin friction measurement in aerodynamic tests using thin liquid crystal coatings with changes in maximum light scattering wavelength in response to shearing forces
Interaction of cells with elastic cholesteryl liquid crystal”, Medical Physic and Biomedical Engineering World Congress, In Press. C D at Tm at Tg at incubation temperature, 37 0 C E n d o
  • Proceedings of the World Congress on Engineering 2009 Vol II WCE 2009,
  • 2009
Cholesteryl compositions, US
  • Patent No. 4301023,
  • 1981
...
1
2
...