Characterization Of Benzoporphyrin Derivative, A New Photosensitizer

@inproceedings{Richter1989CharacterizationOB,
  title={Characterization Of Benzoporphyrin Derivative, A New Photosensitizer},
  author={Anna Richter and Ethan Sternberg and Elizabeth Waterfield and David Dolphin and Julia G. Levy},
  booktitle={Other Conferences},
  year={1989}
}
Benzoporphyrin derivative (BPD), synthesized from protoporphyrin and involving the formation of Diels-Alder adducts, contains four components, mono and di-acid derivatives of either ring A or ring B fused porphyrins. These compounds have been isolated and tested individually as photosensitizers both in vitro and in vivo. All forms of BPD are potent photosensiters in vitro and have a strong absorption peak at about 690 nm. 3H-BPDs were tested for biodistribution in tumor bearing mice… 
40 Citations

Photosensitising potency of structural analogues of benzoporphyrin derivative (BPD) in a mouse tumour model.

The monoacid forms of BPD were found to be much more photodynamically active in this test than were the diacid analogues, and the ability of the analogues to ablate tumours in mice by photodynamic therapy was also tested.

ACTIVATION OF BENZOPORPHYRIN DERIVATIVE IN THE CIRCULATION OF MICE WITHOUT SKIN PHOTOSENSITIVITY

Activation of this photosensitizer in the circulation can be achieved by transdermal light exposure without causing skin photosensitivity provided that light exposure is performed at a time when the first phase of plasma clearance is complete and when the drug has not yet accumulated in skin.

PHOTOPHYSICAL AND PHOTOSENSITIZING PROPERTIES OF BENZOPORPHYRIN DERIVATIVE MONOACID RING A (BPD‐MA) *

The photophysical properties of benzoporphyrin derivative monoacid ring A (BPD‐MA), a second‐generation photosensitizer currently in phase II clinical trials, were investigated in homogeneous solution and a dramatic effect of oxygen on the fluorescence (φf) and intersystem crossing ( φT) quantum yields has been observed.

SITES OF PHOTODAMAGE in vivo and in vitro BY A CATIONIC PORPHYRIN

Pharmacokinetic studies indicate that plasma levels, not tissue levels were the major determinant of photodynamic therapy (PDT) response, and vascular damage and disturbances of tissue perfusion following PDT were more pronounced in tumor‐bearing skin than in normal skin.

Chlorins as photosensitizers in biology and medicine.

  • J. Spikes
  • Chemistry
    Journal of photochemistry and photobiology. B, Biology
  • 1990

Localization of lipoprotein-delivered benzoporphyrin derivative in the rabbit eye.

B PD-MA with LDL rapidly accumulates in the choroid, RPE, and photoreceptors after intravenous injection and future studies of PDT with BPD-MA for the treatment of fundus disorders may need to address the relationship between dye localization and photodynamically-mediated injury.

Laserchemotherapy of Tumours: Clinical Aspects

It is demonstrated that HPD was selectively accumulated by malignant as well as by actively proliferating tissues and produced the first demonstration of endoscopic diagnosis of malignant tissues by detection of fluorescence in the respiratory and in the upper digestive tract.

Absorption spectroscopic analysis of the pharmacokinetics of octa-alpha-butyloxy-zinc phthalocyanine in Lewis lung carcinoma-bearing mice

The phthalocyanines form a continuously growing family of potential photosensitizers. Their chemical and photophysical properties, and therefore their photodynamic activities, are influenced by the

132-hydroxy-bacteriopheophorbidea-methylester pharmacokinetics in mice bearing Lewis lung carcinoma

The photosensitiser 132-hydroxy bacteriopheophorbide a-methylester (132-OH-BPME) is characterised by a high absorption coefficient at the far red wavelength 750 nm and a good singlet oxygen quantum

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