Characterization Of Benzoporphyrin Derivative, A New Photosensitizer

@inproceedings{Richter1989CharacterizationOB,
  title={Characterization Of Benzoporphyrin Derivative, A New Photosensitizer},
  author={Anna Richter and Ethan Sternberg and Elizabeth Waterfield and David Dolphin and Julia G. Levy},
  booktitle={Other Conferences},
  year={1989}
}
Benzoporphyrin derivative (BPD), synthesized from protoporphyrin and involving the formation of Diels-Alder adducts, contains four components, mono and di-acid derivatives of either ring A or ring B fused porphyrins. These compounds have been isolated and tested individually as photosensitizers both in vitro and in vivo. All forms of BPD are potent photosensiters in vitro and have a strong absorption peak at about 690 nm. 3H-BPDs were tested for biodistribution in tumor bearing mice… 
40 Citations

Photosensitising potency of structural analogues of benzoporphyrin derivative (BPD) in a mouse tumour model.

TLDR
The monoacid forms of BPD were found to be much more photodynamically active in this test than were the diacid analogues, and the ability of the analogues to ablate tumours in mice by photodynamic therapy was also tested.

ACTIVATION OF BENZOPORPHYRIN DERIVATIVE IN THE CIRCULATION OF MICE WITHOUT SKIN PHOTOSENSITIVITY

TLDR
Activation of this photosensitizer in the circulation can be achieved by transdermal light exposure without causing skin photosensitivity provided that light exposure is performed at a time when the first phase of plasma clearance is complete and when the drug has not yet accumulated in skin.

MOUSE SKIN PHOTOSENSITIZATION WITH BENZOPORPHYRIN DERIVATIVES AND PHOTOFRIN®: MACROSCOPIC AND MICROSCOPIC EVALUATION

TLDR
Histological examination of biopsies taken after photosensitizer injection and light exposure showed extensive changes in epidermis and dermis, including epidermal erosion, de granulation of the stratum granulosum, spongiosis, depletion in cellularity and mast cell degranulation, similar to changes caused by Photofrin®.

PHOTOPHYSICAL AND PHOTOSENSITIZING PROPERTIES OF BENZOPORPHYRIN DERIVATIVE MONOACID RING A (BPD‐MA) *

TLDR
The photophysical properties of benzoporphyrin derivative monoacid ring A (BPD‐MA), a second‐generation photosensitizer currently in phase II clinical trials, were investigated in homogeneous solution and a dramatic effect of oxygen on the fluorescence (φf) and intersystem crossing ( φT) quantum yields has been observed.

Benzophenothiazine and Benzoporphyrin Derivative Combination Phototherapy Effectively Eradicates Large Murine Sarcomas

TLDR
The data suggest that the enhanced PDT effect observed with the combination of drugs is synergistic rather than additive, and a greater intracellular localization for EtNBS vs BPD‐MA.

Benzoporphyrin derivative and the photodynamic extracorporeal treatment of leukemia

TLDR
Photodynamic purging may be an effective means of eliminating leukemic progenitors from peripheral blood stem cell autogralts while maintaining the capacity of normal PBL stem cells to bone marrow.

Chlorins as photosensitizers in biology and medicine.

  • J. Spikes
  • Chemistry
    Journal of photochemistry and photobiology. B, Biology
  • 1990

Localization of lipoprotein-delivered benzoporphyrin derivative in the rabbit eye.

TLDR
B PD-MA with LDL rapidly accumulates in the choroid, RPE, and photoreceptors after intravenous injection and future studies of PDT with BPD-MA for the treatment of fundus disorders may need to address the relationship between dye localization and photodynamically-mediated injury.

Laserchemotherapy of Tumours: Clinical Aspects

TLDR
It is demonstrated that HPD was selectively accumulated by malignant as well as by actively proliferating tissues and produced the first demonstration of endoscopic diagnosis of malignant tissues by detection of fluorescence in the respiratory and in the upper digestive tract.

References

SHOWING 1-8 OF 8 REFERENCES

Preliminary studies on a more effective phototoxic agent than hematoporphyrin.

TLDR
The most attractive characteristic of BPD in addition to its powerful phototoxicity is its maximum absorption around 700 nm, which is in the range of wavelengths penetrating tissues the best, which could make BPD a drug of choice in cancer photodynamic therapy when the safety of its use is ensured.

Blood flow in transplantable bladder tumors treated with hematoporphyrin derivative and light.

TLDR
Following hematoporphyrin derivative photochemotherapy, disruption of tumor blood flow may be an important mechanism of action of this method of cancer therapy.

Photodynamic therapy (PDT) of malignant tumors.

  • T. Dougherty
  • Medicine
    Critical reviews in oncology/hematology
  • 1984

Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy.

TLDR
In both tumors, it was found to be nearly unaffected by PDT if the tumor tissue was excised and explanted immediately following completion of treatment, indicating that the effect of PDT on tumor cells directly was not sufficient to decrease tumor clonogenicity even at doses which led to total macroscopic tumor destruction.

Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers.

TLDR
In the model system, tumor cell death after photoradiation occurs secondary to destruction of the microcirculation, and it is concluded that, in this system, five of five transplanted tumors did regrow.

Application to proliferation and cytotoxic assays

  • J. of Immunological Methods 65, 55 -63 (1983). 138 / SPIE Vol. 997 Advances in Photochemotherapy
  • 1988