Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues.

@article{Ma2009CharacterizationCI,
  title={Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues.},
  author={Changqing Ma and Kelly M. Quesnelle and Anthony M Sparano and Shilpa J. Rao and Min Seon Park and Marc A Cohen and Yanli Wang and Minu Samanta and M Shubash Kumar and Muhammad Usman Aziz and Tara L. Naylor and Barbara L. Weber and Steven S. Fakharzadeh and G Weinstein and Anil Vachani and Michael D. Feldman and Marcia S. Brose},
  journal={Cancer biology & therapy},
  year={2009},
  volume={8 10},
  pages={907-16}
}
The Cub and Sushi Multiple Domains-1 (CSMD1) is a tumor suppressor gene on 8p23.2, where allelic loss is both frequent and associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). To understand the extent of CSMD1 aberrations in vivo, we characterized 184 primary tumors from the head and neck, lung, breast and skin for gene copy number and analyzed expression in our HNSCCs and lung squamous cell carcinomas (SCCs). We detected loss of CSMD1 in a large proportion of HNSCCs… CONTINUE READING

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