Characterization, in Vivo Evaluation, and Molecular Modeling of Different Propofol-Cyclodextrin Complexes To Assess Their Drug Delivery Potential at the Blood-Brain Barrier Level

@article{Shityakov2016CharacterizationIV,
  title={Characterization, in Vivo Evaluation, and Molecular Modeling of Different Propofol-Cyclodextrin Complexes To Assess Their Drug Delivery Potential at the Blood-Brain Barrier Level},
  author={Sergey Shityakov and Ramin Ekhteiari Salmas and Serdar Durdagi and Ellaine Salvador and Katalin P{\'a}pai and Maria Josefa Y{\'a}{\~n}ez-Gasc{\'o}n and Horacio Emilio P{\'e}rez S{\'a}nchez and Istv{\'a}n Pusk{\'a}s and Norbert Roewer and Carola Y F{\"o}rster and Jens-Albert Broscheit},
  journal={Journal of chemical information and modeling},
  year={2016},
  volume={56 10},
  pages={
          1914-1922
        }
}
In this study, we investigated the ability of the general anesthetic propofol (PR) to form inclusion complexes with modified β-cyclodextrins, including sulfobutylether-β-cyclodextrin (SBEβCD) and hydroxypropyl-β-cyclodextrin (HPβCD). The PR/SBEβCD and PR/HPβCD complexes were prepared and characterized, and the blood-brain barrier (BBB) permeation potential of the formulated PR was examined in vivo for the purpose of controlled drug delivery. The PR/SBEβCD complex was found to be more stable in… CONTINUE READING
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