Characteristics of tolerance, recovery from tolerance and cross-tolerance for cocaine used as a discriminative stimulus.

@article{Wood1986CharacteristicsOT,
  title={Characteristics of tolerance, recovery from tolerance and cross-tolerance for cocaine used as a discriminative stimulus.},
  author={Douglas M. Wood and Michael W. Emmett-Oglesby},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1986},
  volume={237 1},
  pages={120-5}
}
Rats were trained to discriminate an injection of cocaine (10 mg/kg) from saline using a two-lever choice procedure with food as a reinforcer. Subsequently, training was stopped, and cocaine was injected chronically. In one experiment, 10.0 or 20.0 mg/kg/8 hr 8 hr of cocaine for 7 days produced a 2-fold shift to the right of the discriminative stimulus dose-effect curve. A dose of 5.0 mg/kg/8 hr for up to 14 days did not shift the dose-effect curve. In a second experiment, 20 mg/kg/8 hr for 7… CONTINUE READING

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