Characteristics of the transport of oxalate and other ions across rabbit proximal colon

  title={Characteristics of the transport of oxalate and other ions across rabbit proximal colon},
  author={Marguerite Hatch and Robert W. Freel and Nosratola D. Vaziri},
  journal={Pfl{\"u}gers Archiv},
In order to characterize oxalate handling by the P2 segment of the rabbit proximal colon, the fluxes of [14C]oxalate, 22Na+, and 36Cl− were measured in vitro using conventional short-circuiting techniques. In standard buffer the proximal colon exhibited net secretion of Na+ (−2.31±0.64 μequiv cm−2 h−1), negligible net Cl− transport, and net secretion of oxalate (−12.7±1.6 pmol cm−2 h−1). Replacement of buffer Na+ or Cl− abolished net oxalate secretion, while HCO 3 − -free media revealed a net… CONTINUE READING


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