Characteristics of the pupillary light reflex in the macaque monkey: discharge patterns of pretectal neurons.

@article{Pong2000CharacteristicsOT,
  title={Characteristics of the pupillary light reflex in the macaque monkey: discharge patterns of pretectal neurons.},
  author={Milton Pong and Albert F. Fuchs},
  journal={Journal of neurophysiology},
  year={2000},
  volume={84 2},
  pages={
          964-74
        }
}
Anatomical and physiological data have implicated the pretectal olivary nucleus (PON) as the midbrain relay for the pupillary light reflex in a variety of species. To determine the nature of the discharge of pretectal light reflex relay neurons, we recorded their activity in monkeys that were fixating a stationary spot while a full-field random-dot stimulus was flashed on for 1 s. Based on their discharge patterns, neurons in or near the PON came in two varieties. The most prevalent neuron… 
View on PubMed
jn.physiology.org
32 Citations
Highly Influential Citations
2
Background Citations
19
Methods Citations
1
Results Citations
1

32 Citations

Citation Type

Citation Type

Primate pupillary light reflex: receptive field characteristics of pretectal luminance neurons.
TLDR
All three classes of PON neurons contribute to the behaviorally observed pupillomotor field characteristics in which stimuli at the macular produce substantially larger pupillary responses than more peripheral stimuli.
Characteristics of the pupillary light reflex in the macaque monkey: metrics.
TLDR
Except for response latency, the pupillary responses in the two primate species are otherwise quite similar, so any knowledge gained about the neuronal substrate of the simian light reflex can be expected to have considerable relevance when extrapolated to humans.
Pupillary light reflex circuits in the Macaque Monkey: the olivary pretectal nucleus
TLDR
The olivary pretectal nucleus is the first central connection in the pupillary light reflex pathway, the circuit that adjusts the diameter of the pupil in response to ambient light levels, and aspects of the morphology and connectivity are investigated by use of anterograde and retrograde tracers.
The pretectum: connections and oculomotor-related roles.
Investigation of summation mechanisms in the pupillomotor system
TLDR
This study suggests that pupillomotor summation areas consist of both summation and inhibitory zones and show larger diameters than receptive fields of retinal ganglion cells and do not appear to reflect pupillary summation Areas of the pretectal olivary nucleus luminance neurons.
Shaping the pupil’s response to light in the hooded rat
  • R. Clarke
  • Biology
    Experimental Brain Research
  • 2006
TLDR
The sluggish dynamic properties of the iris musculature are responsible for the asymmetries in pupil contraction, dilation, and latencies as well as low flicker fusion frequency and constriction amplitude characteristics of pupil responses to light.
Localization of Neuronal Gain Control in the Pupillary Response
TLDR
Results suggest that the majority of gain-control in the subcortical pupillary pathway occurs at the level of the EWN, and similar, although more variable, relationships were seen using nasal, and temporal hemifield stimuli.
Inhibition of superior colliculus neurons by a GABAergic input from the pretectal nuclear complex in the rat
TLDR
Results indicate that SC projection neurons receive a direct inhibitory input from the ipsilateral PNC and that this input is mediated by GABAA receptors.
Spontaneous activity of rat pretectal nuclear complex neurons in vitro
TLDR
The results indicate that a specific subpopulation of pretectal neurons is capable of generating maintained activity in the absence of any external synaptic input, which depends on a sodium conductance and is independent from calcium currents.
Defining the pupillary component of the perioculomotor preganglionic population within a unitary primate Edinger-Westphal nucleus.
...
1
2
3
4
...

References

SHOWING 1-10 OF 43 REFERENCES
Discharge patterns of neurons in the pretectal nucleus of the optic tract (NOT) in the behaving primate.
TLDR
The firing rates of NOT units were highly dependent on stimulus velocity and exhibited an increase in firing above resting during horizontal (ipsilateral) background movement and/or during smooth pursuit of a moving spot and a decrease in firing during contralateral movement.
Characteristics of the pupillary light reflex in the macaque monkey: metrics.
TLDR
Except for response latency, the pupillary responses in the two primate species are otherwise quite similar, so any knowledge gained about the neuronal substrate of the simian light reflex can be expected to have considerable relevance when extrapolated to humans.
Role of the caudal fastigial nucleus in saccade generation. I. Neuronal discharge pattern.
TLDR
The discharge patterns of cerebellar output cells in the fastigial nucleus were recorded while monkeys tracked a small, jumping spot of light to examine the neural substrate of this control of rapid eye movements, i.e., saccades.
The pupillary light reflex in normal and innate microstrabismic cats, I: Behavior and receptive-field analysis in the nucleus praetectalis olivaris.
TLDR
The investigation of ocular dominance and subthreshold binocular interactions in the NPO of normal and innate microstrabismic cats revealed two possible mechanisms for BSP and its reduction in strabismi subjects, and suggested that BSP may be additionally influenced by visual structures other than NPO.
Response properties of pretectal omnidirectional pause neurons in the behaving primate.
TLDR
A region in the pretectum of rhesus monkeys (Macaca mulatta) that contains units that evince a complete cessation in firing immediately after saccades is identified, and it is unlikely that the pause in pretectal FOPNs is involved with saccade generation.
Cells in the pretectal olivary nucleus are in the pathway for the direct light reflex of the pupil in the rat
Unit analysis of the pretectal nuclear group in the rat
TLDR
The topographical organization of units within Pta, as well as their diverse properties may account for residual visual function in animals with extensive lesions of the main visual pathways.
Anatomical analysis of pupillary reflex pathways in the rhesus monkey
TLDR
The pupillary light reflex was analyzed by producing lesions in afferent and efferent pathways in a series of monkeys and finding ipsilateral reductions in direct and consensual pupillary responses.
Quantitative analysis of visual receptive fields of neurons in nucleus of the optic tract and dorsal terminal nucleus of the accessory optic tract in macaque monkey.
1. The visual receptive field properties of neurons in the nucleus of the optic tract (NOT) in the pretectum and the dorsal terminal nucleus (DTN) of the accessory optic tract were analyzed…
Fixation cells in monkey superior colliculus. I. Characteristics of cell discharge.
1. We studied the role of the superior colliculus (SC) in the control of visual fixation by recording from cells in the rostral pole of the SC in awake monkeys that were trained to perform fixation…
...
1
2
3
4
5
...