Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase.

  title={Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase.},
  author={A Smolen and Harry W. Eckerson and Kok-Wee Gan and Nabil Hailat and Bert N La Du},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={19 1},
Human serum paraoxonase/arylesterase is an esterase with broad substrate specificity. It occurs in two genetically determined allozymic forms, which we have designated types A and B. These allozymes are presumed to be the products of two allelic genes located at the paraoxonase locus on chromosome 7, which is closely linked to the gene for cystic fibrosis. Paraoxonase activity of the B-type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase. The ratio of… CONTINUE READING
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