Characteristics of the chemotactic response of neoplastic cells to a factor derived from the fifth component of complement.

@article{Orr1978CharacteristicsOT,
  title={Characteristics of the chemotactic response of neoplastic cells to a factor derived from the fifth component of complement.},
  author={William F. Orr and James Varani and Peter A Ward},
  journal={The American journal of pathology},
  year={1978},
  volume={93 2},
  pages={405-22}
}
Chemotactic factors for malignant neoplastic cells can be generated from either the fifth component of complement or from leukotactic fractions obtained from zymosanactivated serum. Digestion of the fifth component of complement by trypsin initially produced leukotactic activity, but as digestion continues, leukotactic activity is lost and tumor cell chemotactic activity is generated. Separation of the leukotactic activity is lost and tumor cell chemotactic activity is generated. Separation of… CONTINUE READING

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