Characteristics of symptomatic reflux episodes in patients with non-erosive reflux disease who have a positive symptom index on proton pump inhibitor therapy.

@article{Iwakiri2010CharacteristicsOS,
  title={Characteristics of symptomatic reflux episodes in patients with non-erosive reflux disease who have a positive symptom index on proton pump inhibitor therapy.},
  author={Katsuhiko Iwakiri and Hirohito Sano and Yuriko Tanaka and Noriyuki Kawami and Mariko Umezawa and Seiji Futagami and Yoshio Hoshihara and Tsutomu Nomura and Masao Miyashita and Choitsu Sakamoto},
  journal={Digestion},
  year={2010},
  volume={82 3},
  pages={156-61}
}
BACKGROUND AND AIM The reason that some reflux episodes evoke symptoms is poorly understood, therefore the aim of this study is to assess the determinants of reflux perception in patients with non-erosive reflux disease (NERD) on proton pump inhibitor (PPI) therapy. METHODS Ten NERD patients with persistent symptoms, despite double-dose PPI therapy, were included in this study. All patients had a positive symptom index (SI), which was determined by ambulatory 24-hour combined impedance-pH… CONTINUE READING