Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria.

@article{Wetering2001CharacteristicsOS,
  title={Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria.},
  author={J van de Wetering and Martin van Eijk and Lambert M G van Golde and Thomas Hartung and Jos A. G. van Strijp and Joseph J. Batenburg},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={184 9},
  pages={1143-51}
}
Infection with gram-positive bacteria is a major cause of pneumonia. Surfactant proteins A (SP-A) and D (SP-D) are thought to play an important role in the innate immunity of the lung. Both proteins can bind to gram-positive bacteria. Until now, it was not known with which surface component(s) of gram-positive bacteria SP-A and SP-D interact. Lipoteichoic acid (LTA) and peptidoglycan (PepG) are components of the cell wall of gram-positive bacteria. By use of a solid phase-based binding assay… CONTINUE READING

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