Characteristics of stem cells from human neuroblastoma cell lines and in tumors.

@article{Walton2004CharacteristicsOS,
  title={Characteristics of stem cells from human neuroblastoma cell lines and in tumors.},
  author={J. Walton and David R Kattan and Sharon K Thomas and B. Spengler and Hongfen Guo and J. L. Biedler and N. Cheung and R. Ross},
  journal={Neoplasia},
  year={2004},
  volume={6 6},
  pages={
          838-45
        }
}
Cellular heterogeneity is a hallmark of human neuroblastoma tumors and cell lines. Within a single neuroblastoma are cells from distinct neural crest lineages whose relative abundance is significant for prognosis. We postulate that a self-renewing multipotent tumor stem cell, which gives rise to diverse cell lineages, is the malignant progenitor of this cancer. To test this hypothesis, we have established 22 cloned, phenotypically homogeneous populations of the three major cell types from 17… Expand
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