Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

@article{Miyaki1994CharacteristicsOS,
  title={Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.},
  author={Michiko Miyaki and Motoko Konishi and Rei Kikuchi-Yanoshita and Masatoshi Enomoto and Toru Igari and Kiyoko Tanaka and Masato Muraoka and Hiromi Takahashi and Yoko Amada and Masashi Fukayama},
  journal={Cancer research},
  year={1994},
  volume={54 11},
  pages={3011-20}
}
Mutation of the adenomatous polyposis coli (APC) gene was analyzed in 500 colorectal tumors from 70 familial adenomatous polyposis (FAP) and 102 non-FAP patients and in normal tissues from 119 FAP patients, using polymerase chain reaction-single-strand conformation polymorphism and direct sequencing methods. These tumors were histopathologically diagnosed. Sixty-eight germ line mutations (62% deletion, 9% insertion, and 29% single-base substitution) and 241 somatic mutations (56% deletion, 12… CONTINUE READING
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Mutational analysis of patients with adenomatous polyposis : identical inactivating mutations in unrelated individuals

  • J. Groden, L Gelbert, +8 authors R. White
  • Am . J . Hum . Genet .
  • 1993

Germ - linemutationsof APCgenein 53 familialadenomatous polyposis patients

  • Y. Miyoshi, H. Ando, +10 authors Y. andNakamura
  • Proc . Nail . Acad . Sci . USA
  • 1992

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