Characteristics of sequences around individual nucleotide substitutions in IgVH genes suggest different GC and AT mutators.


Somatic hypermutation affects Ig genes during T-dependent B cell responses and is characterized by a high frequency of single base substitutions. Hypermutation is not a completely random process; a study of mutations in different systems has revealed the presence of sequence motifs that target mutation. In a recent analysis of the sequences surrounding… (More)


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