Characteristics of scrapie isolates derived from hay mites.

@article{Carp2000CharacteristicsOS,
  title={Characteristics of scrapie isolates derived from hay mites.},
  author={R. Carp and H. Meeker and R. Rubenstein and S. Sigurdarson and M. Papini and R. Kascsak and P. Kozlowski and H. Wiśniewski},
  journal={Journal of neurovirology},
  year={2000},
  volume={6 2},
  pages={
          137-44
        }
}
Previous epidemiological evidence suggested that in some instances a vector and/or reservoir is involved in the occurrence and spread of transmissible spongiform encephalopathies (TSEs. [...] Key Result As expected for scrapie, subsequent passages in the same host led to shortened incubation periods compared to those in primary isolate mice, and all mice had spongiform changes in brain.Expand
The early history of the transmissible spongiform encephalopathies exemplified by scrapie
TLDR
The current work comprehensively summarizes the available early literature on TSE research and review of the historical literature is presented, describing the efforts in breeding, transmission experiments, and theories about the nature of the infectious agent. Expand
Myiasis as a risk factor for prion diseases in humans
  • O. Lupi
  • Biology, Medicine
  • Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2006
TLDR
Iatrogenic transmission of Creutzfeldt–Jakob disease was also recognized after corneal transplants in humans and scrapie was successfully transmitted to mice after ocular instillation of infected brain tissue, confirming that these new routes could also be important in prion infections. Expand
Could ectoparasites act as vectors for prion diseases?
  • O. Lupi
  • Biology, Medicine
  • International journal of dermatology
  • 2003
TLDR
Fly larvae and mites were exposed to brain‐infected material and were readily able to transmit scrapie to hamsters, and new lines of evidence have confirmed that adult flies are also able to express prion proteins. Expand
Spiroplasma as a Candidate Agent for the Transmissible Spongiform Encephalopathies
  • F. Bastian
  • Biology, Medicine
  • Journal of neuropathology and experimental neurology
  • 2005
TLDR
Data from an epidemiologic infection model evidence accumulated over the past 30 years showing involvement of Spiroplasma infection in TSE support the hypothesis that a SpiroPLasma sp. Expand
Risk analysis of ectoparasites acting as vectors for chronic wasting disease.
  • O. Lupi
  • Biology, Medicine
  • Medical hypotheses
  • 2005
TLDR
Considering the huge amount of fly larvae that affects each animal, it is important to discuss the possibility that these ectoparasites could theoretically act as reservoirs and vectors for CWD and other prion diseases. Expand
Hay Mite Communities in Sheep Farms from French and Spanish Basque Regions with regard to Scrapie Infection
TLDR
This is the first record of the composition of the hay mite fauna in Spain and France and the finding of differences in mite communities in hay from scrapie versus non-scrapie farms is a further indication of the possible association of certain mite species with scrapie. Expand
Transmissible spongiform encephalopathies in non-domestic animals: origin, transmission and risk factors.
TLDR
These examples illustrate that when non-domestic animals are held in captivity, they depend upon feeds supplied by their caretakers and may show degrees of susceptibility to infectious agents in feeds which vary from those of domestic species. Expand
Potential Role of Soil in the Transmission of Prion Disease
TLDR
CWD and scrapie are the only TSEs that appear to be environmentally transmitted and a familial pattern exists in natural sheep scrapie suggesting that genetics and, possibly, vertical transmission are important. Expand
Bovine spongiform encephalopathy: epidemiology and diagnosis.
TLDR
Control and eradication of BSE will depend on specific and sensitive diagnostic tests that could be applied on live animals early in infection, and several recently published results give some hope that such early diagnostic tests might be available in a near future. Expand
Prions in the environment
TLDR
Conformational changes upon adsorption, competitive sorption, and potential for desorption and transport all warrant further investigation, and changes in PrPSc structure upon environmental exposure may be as significant as changes in prion quantity. Expand
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Two mouse-adapted scrapie agents of different sheep origin were compared: the titre, reached in the brains of mice in the terminal stage of scrapie, is of the same order for both agents, and the implications of this type of host-genotype, agent-strain interaction are discussed. Expand
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TLDR
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