Characteristics of phorbol ester stimulated growth hormone release: inhibition by insulin-like growth factor I, somatostatin, and low calcium medium and comparison with growth hormone releasing factor.

Abstract

TPA (12-O-tetradecanoylphorbol 13-acetate) is one of a class of compounds known as tumor promoters which perturb the inositol phosphate pathway in a number of cells. We have used TPA in a dispersed rat adenohypophysial cell system to probe the characteristics of growth hormone (GH) release. In this system we have found that the cells release GH in response… (More)

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Cite this paper

@article{Sheppard1987CharacteristicsOP, title={Characteristics of phorbol ester stimulated growth hormone release: inhibition by insulin-like growth factor I, somatostatin, and low calcium medium and comparison with growth hormone releasing factor.}, author={Mickie S. Sheppard and Brian Eatock and Rajni Bala}, journal={Canadian journal of physiology and pharmacology}, year={1987}, volume={65 11}, pages={2302-7} }