Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy.

@article{Sugimoto2011CharacteristicsON,
  title={Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy.},
  author={M Sugimoto and Masafumi Nishino and Chise Kodaira and Mihoko Yamade and Takahiro Uotani and Mutsuhiro Ikuma and Kazuo Umemura and T Furuta},
  journal={World journal of gastroenterology},
  year={2011},
  volume={17 14},
  pages={1858-65}
}
AIM To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ: 10 mg or 20 mg od, 20 mg bid, or 10 mg qid for 14 d. All patients completed a frequency scale for symptoms of gastroesophageal reflux disease questionnaire frequency scale for the symptoms of GERD (FSSG); and underwent 24 h pH monitoring on day 14… CONTINUE READING