Characteristics of nitric oxide synthase type I of rat cerebellar astrocytes.

  title={Characteristics of nitric oxide synthase type I of rat cerebellar astrocytes.},
  author={Mar{\'i}a Lourdes Arbon{\'e}s and Joan Ribera and Lu{\'i}s Agull{\'o} and Mar{\'i}a Antonia Baltrons and A. M. Casanovas and Valentina Riveros-Moreno and Agustina Garc{\'i}a},
  volume={18 3},
We have previously reported that stimulation of astrocyte cultures by particular agonists and calcium ionophores induces cyclic GMP formation through activation of a constitutive nitric oxide synthase (NOS) and that astrocytes from cerebellum show the largest response. In the present work we have used rat cerebellar astrocyteenriched primary cultures to identify and characterise the isoform of NOS expressed in these cells. The specific NOS activity in astrocyte homogenates, determined by… CONTINUE READING
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