Characteristics of neutral and deleterious protein-coding variation among individuals and populations.

@article{Fu2014CharacteristicsON,
  title={Characteristics of neutral and deleterious protein-coding variation among individuals and populations.},
  author={Wenqing Fu and Rachel M. Gittelman and Michael J Bamshad and Joshua M. Akey},
  journal={American journal of human genetics},
  year={2014},
  volume={95 4},
  pages={421-36}
}
Whole-genome and exome data sets continue to be produced at a frenetic pace, resulting in massively large catalogs of human genomic variation. However, a clear picture of the characteristics and patterns of neutral and deleterious variation within and between populations has yet to emerge, given that recent large-scale sequencing studies have often emphasized different aspects of the data and sometimes appear to have conflicting conclusions. Here, we comprehensively studied characteristics of… CONTINUE READING