Characteristics of irreversible ATP activation suggest that native skeletal ryanodine receptors can be phosphorylated via an endogenous CaMKII.

@article{Dulhunty2001CharacteristicsOI,
  title={Characteristics of irreversible ATP activation suggest that native skeletal ryanodine receptors can be phosphorylated via an endogenous CaMKII.},
  author={Angela F Dulhunty and Derek R. Laver and S. McKay Curtis and Suzy M. Pace and Claudia Haarmann and Esther M. Gallant},
  journal={Biophysical journal},
  year={2001},
  volume={81 6},
  pages={3240-52}
}
Phosphorylation of skeletal muscle ryanodine receptor (RyR) calcium release channels by endogenous kinases incorporated into lipid bilayers with native sarcoplasmic reticulum vesicles was investigated during exposure to 2 mM cytoplasmic ATP. Activation of RyRs after 1-min exposure to ATP was reversible upon ATP washout. In contrast, activation after 5 to 8 min was largely irreversible: the small fall in activity with washout was significantly less than that after brief ATP exposure. The… CONTINUE READING

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