Characteristics of invasive and noninvasive human colorectal adenocarcinoma cells.

  title={Characteristics of invasive and noninvasive human colorectal adenocarcinoma cells.},
  author={S Aznavoorian and Lance A. Liotta and H. Z. Kupchik},
  journal={Journal of the National Cancer Institute},
  volume={82 18},
A human colon adenocarcinoma cell line (LoVo) established from a lymph node metastasis was used to study properties associated with invasive tumor cells. Human amniotic membranes were used as invasion barriers to select highly invasive and noninvasive subpopulations of cells from the parent LoVo line. Enriched subpopulations were compared with respect to parameters associated with invasion. The invasive cells were more invasive in vitro and more highly sialylated than either the parental or… CONTINUE READING


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