Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice.

@article{Williams2002CharacteristicsOI,
  title={Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice.},
  author={Hel{\'e}n Williams and Jason L Johnson and Kevin George Stephen Carson and Christopher Langdale Jackson},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2002},
  volume={22 5},
  pages={788-92}
}
The brachiocephalic arteries of fat-fed apolipoprotein E knockout mice develop plaques that frequently rupture and form luminal thromboses. The morphological characteristics of plaques without evidence of instability or with healed previous ruptures (intact) and vessels with acutely ruptured plaques (ruptured) have now been defined, to understand the process of plaque destabilization in more detail. Ninety-eight apolipoprotein E knockout mice were fed a diet supplemented with 21% lard and 0.15… CONTINUE READING
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