Characteristics of hypothermic preconditioning influencing the induction of delayed ischemic tolerance.

Abstract

OBJECT A brief period of hypothermia has recently been shown to induce delayed tolerance to ischemic brain injury. This form of tolerance is initiated several hours after hypothermic preconditioning (HPC) and persists for a few days. Hypothermia-induced tolerance could provide a means for limiting cellular injury during predictable periods of ischemia, such… (More)

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