Characteristics of hydrogen bond formation between sugar and polymer in freeze-dried mixtures under different rehumidification conditions and its impact on the glass transition temperature.

@article{Imamura2008CharacteristicsOH,
  title={Characteristics of hydrogen bond formation between sugar and polymer in freeze-dried mixtures under different rehumidification conditions and its impact on the glass transition temperature.},
  author={Koreyoshi Imamura and Yoko Asano and Yoshinobu Maruyama and Tohru Yokoyama and Mayo Nomura and Seiji Ogawa and Kazuhiro Nakanishi},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 3},
  pages={
          1301-12
        }
}
The characteristics of hydrogen bond formation between trehalose and polyvinylpyrrolidone (PVP) in amorphous mixtures at different hydration states were quantitatively investigated. Amorphous trehalose-PVP mixtures were prepared by freeze-drying and equilibrated at different relative humidities (RH). Infrared (IR) spectra of the trehalose-PVP mixtures were obtained by Fourier transform IR spectroscopy,(FTIR) and the IR band corresponding to C=O groups of PVP was deconvolved into the component… 
Fourier Self-Deconvolution Analysis of Hydrogen Bonding States of Polyvinylpyrrolidone in an Amorphous Sugar Matrix Below and Above the Glass Transition Temperature
ABSTRACT In an amorphous mixture of sugar and polyvinylpyrrolidone (PVP), PVP carbonyl groups form hydrogen bonds with sugar hydroxyl groups, thereby improving the physical stability of the amorphous
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We show that the glass transition of a multitude of mixtures containing hydrogen bonding materials correlates strongly with the effective number of hydroxyl groups per molecule, which are available
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Increasing mobility of solute molecules during the heat treatment should allow spatial reordering of some concentrated solute mixtures into thermodynamically favorable multiple phases.
Crystallization characteristics of amorphous trehalose dried from alcohol
Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying
TLDR
The dehydration of the crystalline trehalose dihydrate to substantially amorphous anhydrate occurred during drying, and its ability to serve as a lyoprotectant warrants further investigation.
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