Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent.

  title={Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent.},
  author={Hanns Joachim Weinmann and Robert C. Brasch and W R Press and George E. Wesbey},
  journal={AJR. American journal of roentgenology},
  volume={142 3},
Chelation of the rare-earth element gadolinium (Gd) with diethylenetriaminepentaacetic acid (DTPA) results in a strongly paramagnetic, stable complex that is well tolerated in animals. The strongly paramagnetic gadolinium complex reduces hydrogen-proton relaxation times even in low concentrations (less than 0.01 mmol/L). The pharmacokinetic behavior of intravenously delivered Gd-DTPA is similar to the well known iodinated contrast agents used in urography and angiography; excretion is… CONTINUE READING
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