Characteristics of contractile responses of aorta to norepinephrine in db/db mice.

@article{Kamata1997CharacteristicsOC,
  title={Characteristics of contractile responses of aorta to norepinephrine in db/db mice.},
  author={Katsuo Kamata and Shu-ichi Kojima},
  journal={Research communications in molecular pathology and pharmacology},
  year={1997},
  volume={96 3},
  pages={319-28}
}
In the isolated mouse aorta with endothelium, although norepinephrine (NE) showed only a slight increase in tension in control mice, the NE-induced dose-dependent contraction was markedly increased in spontaneously diabetic mice. NE-induced contractile responses were significantly enhanced by pretreatment with 10(-4) NG-monomethyl-L-arginine (L-NMMA), 5 micrograms/ml lysophosphatidylcholine (LPC), and the combined treatment with L-NMMA and LPC. When the aortic ring was precontracted with 3 x 10… CONTINUE READING

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