Characteristics of ceftriaxone binding to immunoglobulin G and potential clinical significance.

@article{Sun1991CharacteristicsOC,
  title={Characteristics of ceftriaxone binding to immunoglobulin G and potential clinical significance.},
  author={Hong-sui Sun and Moses Sing Sum Chow and Eufronio G. Maderazo},
  journal={Antimicrobial agents and chemotherapy},
  year={1991},
  volume={35 11},
  pages={
          2232-7
        }
}
The interaction between immunoglobulin G (IgG) and ceftriaxone was studied. Using an ultrafiltration method, we performed dose ranging studies at a ceftriaxone concentration range of 1 to 720 micrograms/ml in the presence of various concentrations of human IgG, human serum albumin (HSA), and combinations of IgG and HSA at pH 7.4 and 37 degrees C. The results showed that ceftriaxone binding to IgG was nonlinear and was consistent with the presence of two binding sites that possess different… CONTINUE READING