Characteristics of analgesia induced by noncatecholic phenylethylamine derivatives: possible involvement of endogenous opioid peptides and serotonin in phenylethylamine analog-induced analgesia.

@article{Natsuoka1984CharacteristicsOA,
  title={Characteristics of analgesia induced by noncatecholic phenylethylamine derivatives: possible involvement of endogenous opioid peptides and serotonin in phenylethylamine analog-induced analgesia.},
  author={Y. Natsuoka and M. Sakuma and T. Uruno and K. Kubota},
  journal={Japanese journal of pharmacology},
  year={1984},
  volume={34 3},
  pages={
          277-87
        }
}
  • Y. Natsuoka, M. Sakuma, +1 author K. Kubota
  • Published 1984
  • Chemistry, Medicine
  • Japanese journal of pharmacology
  • Characteristics of the analgesic action of phenylethylamine derivatives, amphetamine, phenylethylamine (PEA), hydroxyphenylethylamine (OHPEA) and hydroxyphenylalanine (OHF), were examined. Pain threshold of mice was measured by using the hot plate method. OHPEA (50 mg/kg), amphetamine (0.5-8 mg/kg) or PEA (50 mg/kg) produced an analgesic effect in the absence of MAO inhibitor, and the analgesia was reversed by naloxone (5 mg/kg) or reserpine (2 mg/kg x 2). Ten mg/kg of PEA, 250 mg/kg of OHF and… CONTINUE READING

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