Characteristics of an uptake system for alpha-aminoisobutyric acid in Leishmania tropica promastigotes.

@article{Lepley1983CharacteristicsOA,
  title={Characteristics of an uptake system for alpha-aminoisobutyric acid in Leishmania tropica promastigotes.},
  author={P R Lepley and Antony J Mukkada},
  journal={The Journal of protozoology},
  year={1983},
  volume={30 1},
  pages={41-6}
}
Leishmania tropica promastigotes transport alpha-aminoisobutyric acid (AIB), the nonmetabolizable analog of neutral amino acids, against a substantial concentration gradient. AIB is not incorporated into cellular material but accumulates within the cells in an unaltered form. Intracellular AIB exchanges with external AIB. Various energy inhibitors (amytal, HOQNO, KCN, DNP, CCCP, and arsenate) and sulfhydryl reagents (NEM, pCMB, and iodoacetate) severely inhibit uptake. The uptake system is… CONTINUE READING