Characteristics of an established cell line of retinoblastoma.

  title={Characteristics of an established cell line of retinoblastoma.},
  author={T. Reid and D. Albert and A. Rabson and P. Russell and J. Craft and E. Chu and T. S. Tralka and J. L. Wilcox},
  journal={Journal of the National Cancer Institute},
  volume={53 2},
Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines
It is proved that RA/BMP-4 apoptosis signaling in WERI-Rb1 cells requires the RA receptor subtypes RARα, RARß, RXRß and RXRγ, and this study provides useful starting-points for future retinoid-based therapy strategies in retinoblastoma. Expand
Cancer stem cell characteristics in retinoblastoma.
Mouse and human retinoblastoma tumor cells contain a small subpopulation of cells that exhibit a cancer stem cell-like phenotype, and especially significant is the expression of ABCG2 in mouse and human tumor cells, a calcium-sensitive cell surface protein that not only acts to exclude Hoechst dye, but also confers resistance to over 20 different chemotherapeutic agents. Expand
Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid
Findings suggest that okadaic-acid-induced apoptosis occurs as a result of metaphase arrest, similar to other mitotic poisons, which induced apoptosis in Y-79 cells. Expand
PhotodynamicKillingof RetinoblastomaCellswith Hematoporphyrin and Light1
A porphyrin-binding plasma factor, hemopexin, which is a natural /3-glycoprotein be lieved to be responsible for the transport of circulating porphyrs to the liver for their elimination is suggested for this phenomenon. Expand
Cultivation of Retinoblastoma Cells: Correlation Between In Vitro Growth Pattern and Histopathology
The adherent growth pattern of cultivated retinoblastoma cells might be associated with tumor differentiation and the lack of optic nerve involvement in histopathology. Expand
Establishment of a novel retinoblastoma (Rb) nude mouse model by intravitreal injection of human Rb Y79 cells – comparison of in vivo analysis versus histological follow up
A novel retinoblastoma nude xenograft mouse model which closely resembles the human disease and allows broad application possibilities and a comparison of in vivo and histological analysis is presented. Expand
Re-characterization of established human retinoblastoma cell lines
Seven established retinoblastoma cell lines are re-characterized with regard to their RB1 mutation status, morphology, growth pattern, endogenous apoptosis levels, colony formation efficiency in soft agar and invasiveness and dissemination capacity in chick chorioallantoic membrane (CAM) assays to provide valuable new details for future therapy-related retinOBlastoma basic research in vitro. Expand
Models and discovery strategies for new therapies of retinoblastoma
This review focuses on the use of models and discovery strategies on translational research in retinoblastoma, and discusses translational applications of hyperthermia, chemotherapy, radiation therapy, and novel targets such as hypoxia, angiogenesis, cellular metabolism, and tumor suppressor functions. Expand
High trefoil factor 1 (TFF1) expression in human retinoblastoma cells correlates with low growth kinetics, increased cyclin-dependent kinase (CDK) inhibitor levels and a selective down-regulation of CDK6
The nuclear localization of TFF1 in CBs—considered to play a role in cell cycle progression, potentially acting as a platform for CDK-cyclin function—offers a new impetus in the ongoing search for potential TFF 1 interacting proteins. Expand
Changes in Retinoblastoma Cell Adhesion Associated with Optic Nerve Invasion
Detailed analysis of the first mouse retinoblastoma cell lines with targeted deletions of the Rb family as they were propagated in culture from the primary tumor shows that changes in cadherin-mediated cell adhesion are associated with retinOBlastoma invasion of the optic nerve prior to metastasis. Expand