Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve.

  title={Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve.},
  author={Carlos Matute},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 17},
  • Carlos Matute
  • Published 1998 in
    Proceedings of the National Academy of Sciences…
Macroglial cells express ionotropic glutamate receptors. In the adult optic nerve, reverse transcription-PCR showed that the native receptors are formed by subunits belonging to the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate classes. Because activation of AMPA and kainate receptors can be toxic to oligodendrocytes in vitro, I examined the nature of the damage caused by kainate, an agonist of both receptor classes, applied directly onto the optic nerve. Acute… CONTINUE READING
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Matute Proc

  • W. Stoffel, J. Sasse, +6 authors 189–193. 10234 Neurobiology
  • Natl. Acad. Sci. USA 95
  • 1998

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