Characteristics of a cancerous cell line, HIOEC-B(a)P-96, induced by benzo(a)pyrene from human immortalized oral epithelial cell line.

@article{Zhong2008CharacteristicsOA,
  title={Characteristics of a cancerous cell line, HIOEC-B(a)P-96, induced by benzo(a)pyrene from human immortalized oral epithelial cell line.},
  author={Lai-ping Zhong and Hong-ya Pan and Xiao-jian Zhou and Dong-xia Ye and Lei Zhang and Xiao Yang and Wantao Chen and Zhiyuan Zhang},
  journal={Archives of oral biology},
  year={2008},
  volume={53 5},
  pages={443-52}
}
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial region. The mechanism of carcinogenesis of OSCC is still unclear. In vitro study on OSCC cell lines, especially derived from immortalized oral epithelial cells, is a very useful strategy to understand the mechanism of carcinogenesis. Based on our previous human immortalized oral epithelial cell (HIOEC) line, obtained from normal oral epithelial cells by transfection of HPV16 E6/E7 gene, a new… CONTINUE READING

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