Characteristics of P2X7 receptors from human B lymphocytes expressed in Xenopus oocytes.

@article{Klapperstueck2000CharacteristicsOP,
  title={Characteristics of P2X7 receptors from human B lymphocytes expressed in Xenopus oocytes.},
  author={Manuela Klapperstueck and Cora B{\"u}ttner and Thomas Dipl Ing Boehm and Guenther Schmalzing and Fritz Markwardt},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1467 2},
  pages={
          444-56
        }
}
Human B lymphocytes express an ATP-gated ion channel (P2Z receptor), which shares similarities with the recently identified P2X7 receptor. Using gene specific primers, we have now isolated P2X7 cDNA from the total RNA of human B lymphocytes. This hP2X7 receptor subtype was expressed in Xenopus oocytes and electrophysiologically characterized. The hP2X7 receptor is similar to, but does not completely match, P2Z of human B cells. The hP2X7 receptors resemble the P2Z receptors with regard to the… CONTINUE READING
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