Characteristics of Experimental Autoimmune Hypophysitis in Rats: Major Antigens are Growth Hormone, Thyrotropin, and Luteinizing Hormone in this Model.

Abstract

We produced experim entalautoimmune hypophysitis (EAH) in rats and investi gated its characteristics. Female Lewis rats were immunized by two injections with homologous pituitary homogenate and complete Freund's adjuvant. Blood was coll ected seri ally from the rats, and serum antibodies to pituitary antigens were examined . The rats were sacrificed 2 or 4… (More)
DOI: 10.1080/08916934.2002.11873703

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