Characteristics of Dihydroxyphenylalanine/5‐Hydroxytryptophan Decarboxylase Activity in Brain and Liver of Cat

  title={Characteristics of Dihydroxyphenylalanine/5‐Hydroxytryptophan Decarboxylase Activity in Brain and Liver of Cat},
  author={Sylvie Bouchard and C{\'e}line Bousquet and Andr{\'e}e G. Roberge},
  journal={Journal of Neurochemistry},
Abstract: Dihydroxyphenylalanine/5‐hydroxytryptophan (DOPA/5‐HTP) decarboxylase activity varied widely in different parts of the CNS, being highest in the neostriatum and lowest in the frontal cortex. The addition of 2.5 μm‐pyridoxal 5′‐phosphate (PLP), the coenzyme, increased enzyme activity in brainstem and liver, while higher concentrations led to a decrease in activity. In brainstem, the addition of 1000 μm PLP shows activity similar to that obtained without exogenous PLP. The effects of… Expand
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  • L. Dyck
  • Chemistry, Medicine
  • Life sciences
  • 1987
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