Characteristics of CD59 up-regulation induced in porcine endothelial cells by alphaGal ligation and its association with protection from complement.

@article{Grubbs2003CharacteristicsOC,
  title={Characteristics of CD59 up-regulation induced in porcine endothelial cells by alphaGal ligation and its association with protection from complement.},
  author={Brian C Grubbs and Barbara Benson and Agustin P. Dalmasso},
  journal={Xenotransplantation},
  year={2003},
  volume={10 5},
  pages={387-97}
}
BACKGROUND Activation of endothelial cells may result in proinflammatory and procoagulant changes, or in changes that protect the endothelial cells (EC) from injurious insults. Stimulation of porcine EC with human anti-porcine antibodies, or lectins from Bandeiraea simplicifolia that bind terminal Galalpha(1-3)Gal (abbreviated alphaGal), can induce EC protection from cytotoxicity by human complement. These EC also exhibit up-regulation of CD59 protein and mRNA expression. Porcine CD59 has been… CONTINUE READING