Characteristics and time course of severe glimepiride- versus glibenclamide-induced hypoglycaemia

  title={Characteristics and time course of severe glimepiride- versus glibenclamide-induced hypoglycaemia},
  author={Andreas Holstein and Armin Plaschke and Claude Hammer and E. H. Egberts},
  journal={European Journal of Clinical Pharmacology},
Objective. To compare the clinical characteristics and time course of severe hypoglycaemia (SH) on glimepiride and the reference drug glibenclamide. Methods. SH was defined as a symptomatic event requiring administration of i.v. glucose or of glucagon. Four hundred doctors working in acute care hospitals were randomly selected from the membership directory of the German Diabetes Association and sent a standardised questionnaire about sulphonylurea-induced SH that occurred between June 2001 and… CONTINUE READING
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