Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography.


BACKGROUND Macular telangiectasia type 2 (MacTel 2) is a bilateral idiopathic, rare neurodegenerative disease with alterations in the macular capillary network leading to vision loss and is the most common of three subtypes. Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality which helps understand the complex pathological changes, and images the blood vessels across different layers based on their flow characteristics. METHODS A cross-sectional study was conducted on 56 eyes of Asian Indian eyes of 28 consecutive patients with MacTel 2 studied during a 3-month period in a tertiary eye care hospital of South India. Clinically diagnosed cases of MacTel 2 underwent fundus photography, spectral domain OCT and OCTA. Fluorescein angiography was performed only when clinically indicated. Mean capillary density was calculated using a MATLAB-based automated software. The images were thresholded and binarised to derive the mean value. RESULTS The mean age at presentation was 60±5.2, with a female preponderance of 71.42%. Vascular network on OCTA shows an increase in the intervascular spaces with progressive capillary rarefaction and abnormal capillary anastomosis. The outer retina and choroid were involved during the later stages and showed a prominent vascular network. The mean capillary density of the superficial and deep layers was 39.99% and 39.03% as against 45.18% and 44.21% in the controls, respectively. There was a statistically significant difference between the two groups (p<0.01). There is a positive and statistically significant correlation between the superficial and deep layers. CONCLUSION OCTA helps understand the pathology and disease progression better in MacTel 2.

DOI: 10.1136/bjophthalmol-2015-307941


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@article{Chidambara2016CharacteristicsAQ, title={Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography.}, author={Lavanya Chidambara and Santosh G K Gadde and Naresh Kumar Yadav and Chaitra Jayadev and Devanshi Ramji Bhanushali and Abhishek M. Appaji and Mukunda C. Akkali and Aruj Khurana and Rohit Shetty}, journal={The British journal of ophthalmology}, year={2016}, volume={100 11}, pages={1482-1488} }