Characteristics and evaluation of an injectable clarithromycin lipid-based complex in vitro and in vivo.

@article{Ma2013CharacteristicsAE,
  title={Characteristics and evaluation of an injectable clarithromycin lipid-based complex in vitro and in vivo.},
  author={Yan Ma and Haigang Li and Shixia Guan},
  journal={Drug delivery},
  year={2013},
  volume={20 8},
  pages={349-55}
}
The purpose of this paper is to prepare a less-irritating and lipid-based clarithromycin complex (LCC) by the route of intravenous administration qualified with high drug-loading and fine particle size. The LCC was prepared by the injection of organic solvent phase (containing clarithromycin, sodium cholesterol sulfate and phospholipid at a molar ratio of 1:1:1.5) into the Tris buffer solution (0.05 M, pH 7.2) at 40 °C, and then was concentrated by ultrafiltration to remove the organic solvent… CONTINUE READING