Characteristics and effect of antiinflammatory drugs on adriamycin-induced inflammation in the mouse paw


A subplantar injection of 5–100 μg adriamycin in the mouse hind paw produced a biphasic inflammatory response. The first phase peaked at 2h while the second, more severe phase peaked at four to five days. The magnitude of inflammation was dose related. Administration of [3H]adriamycin revealed that 78% of the drug was lost from the paw within one day. The… (More)
DOI: 10.1007/BF00914168

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