Characteristics and distribution of endogenous RFamide-related peptide-1.

  title={Characteristics and distribution of endogenous RFamide-related peptide-1.},
  author={Shoji Fukusumi and Yugo Habata and Hiromi Yoshida and Norio Iijima and Yuji Kawamata and Masaki Hosoya and Ryo Fujii and Shuji Hinuma and Chieko Kitada and Yasushi Shintani and Midori Suenaga and Haruo Onda and Osamu Nishimura and Masashi Tanaka and Yasuhiko Ibata and Masahiko Fujino},
  journal={Biochimica et biophysica acta},
  volume={1540 3},
We have recently identified RFamide-related peptide (RFRP) gene that would encode three peptides (i.e., RFRP-1, -2, and -3) in human and bovine, and demonstrated that synthetic RFRP-1 and -3 act as specific agonists for a G protein-coupled receptor OT7T022. However, molecular characteristics and tissue distribution of endogenous RFRPs have not been determined yet. In this study, we prepared a monoclonal antibody for the C-terminal portion of rat RFRP-1. As this antibody could recognize a… CONTINUE READING
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