Characteristics and determinants of T-cell phenotype normalization in HIV-1-infected individuals receiving long-term antiretroviral therapy.

@article{Ndumbi2014CharacteristicsAD,
  title={Characteristics and determinants of T-cell phenotype normalization in HIV-1-infected individuals receiving long-term antiretroviral therapy.},
  author={Patricia Ndumbi and Jennifer E Gillis and Janet M. Raboud and Cyrus Cooper and Robert S Hogg and Julio S. G. Montaner and Ann N Burchell and Mona Loutfy and Nim{\^a} Machouf and Marina B Klein and Christos M. Tsoukas},
  journal={HIV medicine},
  year={2014},
  volume={15 3},
  pages={
          153-64
        }
}
OBJECTIVES Although combination antiretroviral therapy (cART) can restore CD4 T-cell numbers in HIV infection, alterations in T-cell regulation and homeostasis persist. We assessed the incidence and predictors of reversing these alterations with cART. METHODS ART-naïve adults (n = 4459) followed within the Canadian Observational Cohort and exhibiting an abnormal T-cell phenotype (TCP) prior to cART initiation were studied. Abnormal TCP was defined as having (1) a low CD4 T-cell count (< 532… CONTINUE READING
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