Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.

@article{Sugitani2015CharacteristicsAC,
  title={Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.},
  author={Norie Sugitani and Walter J Chazin},
  journal={Progress in biophysics and molecular biology},
  year={2015},
  volume={117 2-3},
  pages={206-211}
}
DNA replication, damage response and repair require the coordinated action of multi-domain proteins operating within dynamic multi-protein machines that act upon the DNA substrate. These modular proteins contain flexible linkers of various lengths, which enable changes in the spatial distribution of the globular domains (architecture) that harbor their essential biochemical functions. This mobile architecture is uniquely suited to follow the evolving substrate landscape present over the course… CONTINUE READING
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