Characteristics and a functional implication of Ca2+-activated K+ current in mouse aortic endothelial cells

@article{Ahn2003CharacteristicsAA,
  title={Characteristics and a functional implication of Ca2+-activated K+ current in mouse aortic endothelial cells},
  author={Seung Cheol Ahn and Geun Hee Seol and Ji Aee Kim and Suk Hyo Suh},
  journal={Pfl{\"u}gers Archiv},
  year={2003},
  volume={447},
  pages={426-435}
}
We employed the patch-clamp technique to investigate a Ca2+-activated K+ (KCa) current in cultured mouse aortic endothelial cells (MAECs). In the whole-cell mode, an increase in cytosolic [Ca2+] ([Ca2+]i) to 2 µM activated an outwards current. The [K+]o-dependent change of the reversal potentials agreed well with the predicted Nernstian relation, suggesting that it was a KCa current. The Hill coefficient (4) and EC50 (740 nM) were obtained from the current/[Ca2+]i relationship. Iberiotoxin (50… CONTINUE READING

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