Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France.

@article{Guibert2017CharacteristicsAO,
  title={Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France.},
  author={Nicolas M Guibert and Fabrice Barl{\'e}si and Renaud Descourt and Herv{\'e} L{\'e}na and Benjamin Besse and Mich{\'e}le Beau-Faller and Jean Mosser and Eric Pichon and Jean-Philippe Merlio and L'houcine Ouafik and François Guichard and B{\'e}n{\'e}dicte Mastroianni and Lionel Moreau and Annie Wdowik and Jean Christophe Sabourin and Antoinette Lemoine and Pascale Missy and Alexandra Langlais and Denis L Moro-Sibilot and Julien Mazi{\`e}res},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2017},
  volume={12 6},
  pages={
          963-973
        }
}
INTRODUCTION Little is known about the prevalence, prognosis, and response to treatment of advanced NSCLC harboring multiple genomic alterations. METHODS The French Biomarkers France database, which includes 17,664 patients, was used. The prevalence of multiple alterations, their associations, their impact on prognosis (overall survival [OS]), and their response to targeted or conventional treatments (progression-free survival [PFS] and objective response rate) were assessed and compared with… CONTINUE READING
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