Characteristics , Detection , and Clinical Relevance of Alloantibodies in Kidney Transplantation 17 enables the prospective detection of low concentrations of DSAs

@inproceedings{Lobashevsky2017CharacteristicsD,
  title={Characteristics , Detection , and Clinical Relevance of Alloantibodies in Kidney Transplantation 17 enables the prospective detection of low concentrations of DSAs},
  author={Andrew A Lobashevsky},
  year={2017}
}
Almost four decades ago, Porter (Porter, 1970) and Edelman (Edelman, 1970) established the structure of antibodies (immunoglobulins). This discovery dramatically improved the understanding that antibodies function as both receptor and effector molecules. Humoral or antibody-mediated immunity requires noncovalent contact between antigens (ligands) and antibodies (receptors). Hypervariable regions of immunoglobulin light and heavy chains 1, 2, and 3, which are termed complementarity-determining… CONTINUE READING