Characteristics, causes and evolutionary consequences of male-biased mutation.

  title={Characteristics, causes and evolutionary consequences of male-biased mutation.},
  author={Hans Ellegren},
  journal={Proceedings. Biological sciences},
  volume={274 1606},
Mutation has traditionally been considered a random process, but this paradigm is challenged by recent evidence of divergence rate heterogeneity in different genomic regions. One facet of mutation rate variation is the propensity for genetic change to correlate with the number of germ cell divisions, reflecting the replication-dependent origin of many mutations. Haldane was the first to connect this association of replication and mutation to the difference in the number of cell divisions in… CONTINUE READING


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