Characteristic retinal atrophy with secondary "inverse" optic atrophy identifies vigabatrin toxicity in children.

  title={Characteristic retinal atrophy with secondary "inverse" optic atrophy identifies vigabatrin toxicity in children.},
  author={J. Raymond Buncic and Carol A. Westall and Carole M. Panton and J Robert Munn and Leslie D Mackeen and William J. Logan},
  volume={111 10},
OBJECTIVE To describe the clinical pattern of retinal atrophy in children caused by the anticonvulsant vigabatrin. DESIGN An interventional case series report. PARTICIPANTS One hundred thirty-eight patients, mainly infants, were evaluated regularly for evidence of possible vigabatrin toxicity in the Eye and Neurology clinics at the Hospital for Sick Children, Toronto. METHOD Sequential clinical and electroretinographic (International Society for Clinical Electrophysiology of Vision… CONTINUE READING


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