Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias.

@article{Suga2000CharacteristicEO,
  title={Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias.},
  author={Moritaka Suga and Kazuhiro Iyonaga and Tatsuya Okamoto and Y Gushima and Hisako Miyakawa and Takaaki Akaike and Masaru Ando},
  journal={American journal of respiratory and critical care medicine},
  year={2000},
  volume={162 5},
  pages={1949-56}
}
Destruction of subepithelial basement membrane is a key event in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To evaluate the role of matrix metalloproteinases (MMPs) in parenchymal remodeling in idiopathic interstitial pneumonia (IIP), we studied MMP-2 and -9 activity, in bronchoalveolar lavage fluid (BALF) by zymography and the expression of MMP-2 and -9 and TIMP-2 in lung tissue by immunohistochemistry. BALF and lung tissues were collected from 26 patients with usual interstitial… CONTINUE READING

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